EGFR-IN-110 (Compound 6) is a covalent EGFR inhibitor with pIC50 values of 9.2 and 8.7 for EGFR enzyme and EGFR cells, respectively. EGFR-IN-110 shows high EGFR potency and good kinase selectivity.

Physicochemical Properties

Molecular Formula	C22H16CLFN4O2
Molecular Weight	422.84
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS Medicinal Chemistry Letters, 2024.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3650 mL	11.8248 mL	23.6496 mL
	5 mM	0.4730 mL	2.3650 mL	4.7299 mL
	10 mM	0.2365 mL	1.1825 mL	2.3650 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.