EGFR-IN-108 (Compound 12) is a selective covalent EGFR inhibitor (pIC50: 9.4).

Physicochemical Properties

Molecular Formula	C25H23CLFN5O2
Molecular Weight	479.93
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR.ACS Med. Chem. Lett. 2024https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00425.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0836 mL	10.4182 mL	20.8364 mL
	5 mM	0.4167 mL	2.0836 mL	4.1673 mL
	10 mM	0.2084 mL	1.0418 mL	2.0836 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.