EGFR-IN-104 (Compound A23) is a potent EGFR inhibitor with IC50 values of 0.33 μM and 0.133 μM for EGFRL858R/T790M and EGFRDel19/T790M/C797S, respectively. EGFR-IN-104 exhibits anticancer activities in vitro and in vivo.

Physicochemical Properties

Molecular Formula	C23H27N7OS
Molecular Weight	449.57
CAS #	2758904-45-7
SMILES	OC1C=CC=CC=1C1N=C2CCSCC2=C(N=1)NCC1=CN=C(N2CCN(CC2)C)N=C1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	EGFRL858R/T790M 0.33 μM (IC50); EGFRL858R/T790M/C797S 0.133 μM (IC50)
References	[1]. Novel bioactive 2-phenyl-4-aminopyrimidine derivatives as EGFRDel19/T790M/C797S inhibitors for the treatment of non-small cell lung cancer. Arch Pharm (Weinheim). 2024 Feb;357(2):e2300460.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2243 mL	11.1217 mL	22.2435 mL
	5 mM	0.4449 mL	2.2243 mL	4.4487 mL
	10 mM	0.2224 mL	1.1122 mL	2.2243 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.