EGFR-IN-102 (compound 6) is an orally active EGFR inhibitor with IC50 of 2 nM, which can be used in the study of non-small cell lung cancer.

Physicochemical Properties

Molecular Formula	C37H37F2N7O2S
Molecular Weight	681.80
CAS #	2781912-10-3
SMILES	N(C(C(C1=C2CCC3(CC3)N2C=N1)N1C=C2C(=N1)C(C)=C(C#CC1=CC=C(CN3CCC(CC3)CO)C=C1)C=C2C(F)F)=O)C1SC=CN=1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer. ACS Med. Chem. Lett. 2024.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4667 mL	7.3335 mL	14.6671 mL
	5 mM	0.2933 mL	1.4667 mL	2.9334 mL
	10 mM	0.1467 mL	0.7334 mL	1.4667 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.