EAPB0503 is a quinoxaline compound with antitumor activity and strong cytotoxicity to melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, resulting in an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 can also reduce BCR-ABL protein levels.

Physicochemical Properties

Molecular Formula	C18H16N4O
Molecular Weight	304.35
CAS #	1140627-77-5
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Quantitation of imidazo1,2-aquinoxaline derivatives in human and rat plasma using LC/ESI-MS. J. Sep. Sci. 2009, 32, 1363-1373. [2]. EAPB0503, a novel imidazoquinoxaline derivative, inhibits growth and induces apoptosis in chronic myeloid leukemia cells. Anticancer Drugs. 2014 Jul;25(6):624-32.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2857 mL	16.4285 mL	32.8569 mL
	5 mM	0.6571 mL	3.2857 mL	6.5714 mL
	10 mM	0.3286 mL	1.6428 mL	3.2857 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.