E17241 is an inducer of ABCA1 expression and increases the protein level of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs). E17241 reduces plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose diet (HFHG).

Physicochemical Properties

Molecular Formula	C15H14N2O2S2
Molecular Weight	318.41
CAS #	1060968-92-4
SMILES	S1CCSC1C1C=CC(C(NC2C(=CC=CN=2)O)=O)=CC=1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024 Mar;172:116220. [2]. E17241 as a novel ABCA1 (ATP-binding cassette transporter A1) upregulator ameliorates atherosclerosis in miceJ. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41(6): e284-e298.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1406 mL	15.7030 mL	31.4060 mL
	5 mM	0.6281 mL	3.1406 mL	6.2812 mL
	10 mM	0.3141 mL	1.5703 mL	3.1406 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.