Physicochemical Properties
| Molecular Formula | C22H24O4S |
| Molecular Weight | 384.49 |
| CAS # | 824932-88-9 |
| Related CAS # | Elafibranor;923978-27-2 |
| SMILES | CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)C=CC(=O)C2=CC=C(C=C2)SC |
| Synonyms | (E/Z)-GFT505 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | EC50: 45 nM (PPAR-α), 175 nM (PPAR-δ)[1] |
| References |
[1]. Early investigational drugs targeting PPAR-α for the treatment of metabolic disease.Expert Opin Investig Drugs. 2015 May;24(5):611-21. [2]. Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology. 2016 May;150(5):1147-1159. [3]. The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.Diab Vasc Dis Res. 2014 Nohttps://www.ncbi.nlm.nih.gov/pubmed/25212694. |
Solubility Data
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6008 mL | 13.0042 mL | 26.0085 mL | |
| 5 mM | 0.5202 mL | 2.6008 mL | 5.2017 mL | |
| 10 mM | 0.2601 mL | 1.3004 mL | 2.6008 mL |