Drp1 peptide inhibitor P110 (Compound P110) is a selective Drp1 peptide inhibitor with neuroprotective effects. Drp1 peptide inhibitor P110 can inhibit the activation of Drp1, prevent MPTP-induced Drp1 mitochondrial translocation, and reduce MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage and behavioral defects, and can be used in the study of Alzheimer's disease. Drp1 peptide inhibitor P110 can also reduce mitochondrial damage and organ damage in animal models of Huntington's disease, cerebral ischemic injury and myocardial infarction.

Physicochemical Properties

Molecular Formula	C100H179N45O25
Molecular Weight	2411.78
CAS #	2770267-63-3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTPJ. Scientific reports, 2016, 6(1): 32656.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.4146 mL	2.0732 mL	4.1463 mL
	5 mM	0.0829 mL	0.4146 mL	0.8293 mL
	10 mM	0.0415 mL	0.2073 mL	0.4146 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.