Drometrizole is a cosmetic ingredient that works as a UV absorber. No significant toxicity was observed with Drometrizole in acute oral, inhalation, or dermal toxicity studies.

Physicochemical Properties

Molecular Formula	C13H11N3O
Molecular Weight	225.25
Exact Mass	225.09
CAS #	2440-22-4
PubChem CID	17113
Appearance	White to off-white solid powder
Density	1.38
Boiling Point	276.1ºC at 760mmHg
Melting Point	125.5-129.5 °C(lit.)
Flash Point	133.9ºC
Vapour Pressure	4.81E-07mmHg at 25°C
Index of Refraction	1.765
LogP	2.434
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	17
Complexity	259
Defined Atom Stereocenter Count	0
InChi Key	MCPKSFINULVDNX-UHFFFAOYSA-N
InChi Code	InChI=1S/C13H11N3O/c1-9-6-7-13(17)12(8-9)16-14-10-4-2-3-5-11(10)15-16/h2-8,17H,1H3
Chemical Name	2-(benzotriazol-2-yl)-4-methylphenol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber. Toxicol Res. 2019;35(2):119-129.
Additional Infomation	Drometrizole is a member of triazoles.

Solubility Data

Solubility (In Vitro)

DMSO: 50 mg/mL (221.98 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.10 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), suspension solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.4395 mL	22.1976 mL	44.3951 mL
	5 mM	0.8879 mL	4.4395 mL	8.8790 mL
	10 mM	0.4440 mL	2.2198 mL	4.4395 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.