Dopamine D2 receptor blocker (antagonist)-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with submillimolar affinity.

Physicochemical Properties

Molecular Formula	C14H17N3S
Molecular Weight	259.369881391525
Exact Mass	259.114
CAS #	1055411-77-2
PubChem CID	145712390
Appearance	White to off-white solid powder
LogP	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	18
Complexity	307
Defined Atom Stereocenter Count	0
InChi Key	ANUJDLRACOBTTB-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H17N3S/c1-2-7-11-10(6-1)12-13(17-9-4-3-5-9)15-8-16-14(12)18-11/h8-9H,1-7H2,(H,15,16,17)
Chemical Name	N-cyclobutyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Solubility Data

Solubility (In Vitro)

DMSO : ~250 mg/mL (~963.87 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 6.25 mg/mL (24.10 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.8555 mL	19.2775 mL	38.5550 mL
	5 mM	0.7711 mL	3.8555 mL	7.7110 mL
	10 mM	0.3855 mL	1.9277 mL	3.8555 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.