Diminutol is an inhibitor of NADP-dependent quinone oxidoreductase (NQO1), which is involved in regulating microtubule morphogenesis and cell division.

Physicochemical Properties

Molecular Formula	C19H26N6OS
Molecular Weight	386.51
CAS #	361431-33-6
SMILES	CC(C)C(CO)NC1=NC2=C(C(=N1)SC3=CC=CC(=C3)N)N=CN2C(C)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Diminutol (0-100 μM) inhibits microtubule polymerization by shortening interphase and preventing spindle formation during mitosis [1].
References	[1]. Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol. 2004 Jan;11(1):135-46.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5873 mL	12.9363 mL	25.8726 mL
	5 mM	0.5175 mL	2.5873 mL	5.1745 mL
	10 mM	0.2587 mL	1.2936 mL	2.5873 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.