Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) may be utilized to prepare cyclic ketone inhibitors that inhibit the serine protease plasmin.

Physicochemical Properties

Molecular Formula	C₄H₆O₂
Molecular Weight	86.09
Exact Mass	86.036
CAS #	22929-52-8
PubChem CID	529392
Appearance	Colorless to light yellow liquid（Density：1.1124 g/cm3）
Density	1.1±0.1 g/cm3
Boiling Point	151.1±23.0 °C at 760 mmHg
Flash Point	56.3±16.2 °C
Vapour Pressure	3.7±0.3 mmHg at 25°C
Index of Refraction	1.442
LogP	-1.14
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	6
Complexity	67.9
Defined Atom Stereocenter Count	0
SMILES	O1C([H])([H])C(C([H])([H])C1([H])[H])=O
InChi Key	JLPJFSCQKHRSQR-UHFFFAOYSA-N
InChi Code	InChI=1S/C4H6O2/c5-4-1-2-6-3-4/h1-3H2
Chemical Name	oxolan-3-one
Synonyms	Dihydrofuran3(2H)one; Dihydrofuran 3(2H) one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Oxolan-3-one is an oxalane substituted by an oxo group at position 3. It is functionally related to an oxolane.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~1161.58 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 10 mg/mL (116.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 100.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 10 mg/mL (116.16 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 100.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 10 mg/mL (116.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 100.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	11.6158 mL	58.0788 mL	116.1575 mL
	5 mM	2.3232 mL	11.6158 mL	23.2315 mL
	10 mM	1.1616 mL	5.8079 mL	11.6158 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.