Destruxin B2 (compound 5) is a natural destruxin that inhibits the secretion of hepatitis B surface antigen (HBsAg) in Hep3B cells with IC50 of 1.30 μM.

Physicochemical Properties

Molecular Formula	C29H49N5O7
Molecular Weight	579.73
CAS #	79386-00-8
SMILES	CC(C)CC1OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(NC(=O)C2CCCN2C1=O)C(C)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem Biophys Res Commun. 1996 Dec 4;229(1):65-72.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7249 mL	8.6247 mL	17.2494 mL
	5 mM	0.3450 mL	1.7249 mL	3.4499 mL
	10 mM	0.1725 mL	0.8625 mL	1.7249 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.