Deprodone propionate (RD-20000; RD 20000; RD20000) is a corticosteroid which is obtained by esterifying with propionic acid the 17-position of the prednisolone skeleton and deoxidating its 21-position.
Physicochemical Properties
| Molecular Formula | C24H32O5 |
| Molecular Weight | 400.51 |
| Exact Mass | 400.225 |
| CAS # | 20424-00-4 |
| PubChem CID | 443972 |
| Appearance | White to off-white solid powder |
| Density | 1.2 g/cm3 |
| Boiling Point | 540.6ºC at 760 mmHg |
| Flash Point | 180.9ºC |
| Vapour Pressure | 6.07E-14mmHg at 25°C |
| Index of Refraction | 1.566 |
| LogP | 3.546 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Heavy Atom Count | 29 |
| Complexity | 825 |
| Defined Atom Stereocenter Count | 7 |
| SMILES | C[C@@]12[C@@](C(C)=O)(CC[C@@]1([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([H])[C@@H](O)C2)OC(CC)=O |
| InChi Key | DRSFVGQMPYTGJY-GNSLJVCWSA-N |
| InChi Code | InChI=1S/C24H32O5/c1-5-20(28)29-24(14(2)25)11-9-18-17-7-6-15-12-16(26)8-10-22(15,3)21(17)19(27)13-23(18,24)4/h8,10,12,17-19,21,27H,5-7,9,11,13H2,1-4H3/t17-,18-,19-,21+,22-,23-,24-/m0/s1 |
| Chemical Name | [(8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate |
| Synonyms | RD-20000;RD 20000;RD20000 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | As a potent ingredient, deprodone propionate can work for extended periods of time, exhibit maximum effect, cause no skin irritation, and have physicochemical stability. Because of the suspending agent's thickening effect, deprodone propionate can be kept in a state of stable suspension[1]. |
| Additional Infomation | Deprodone propionate is a corticosteroid hormone. |
Solubility Data
| Solubility (In Vitro) | DMSO : ~250 mg/mL (~624.20 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.19 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.19 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (5.19 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4968 mL | 12.4841 mL | 24.9682 mL | |
| 5 mM | 0.4994 mL | 2.4968 mL | 4.9936 mL | |
| 10 mM | 0.2497 mL | 1.2484 mL | 2.4968 mL |