DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase with EC50 values of 0.33, 1.9, 0.76 and 0.066 µM for HCMV, HSV-1, HSV-2 and EBV, respectively.

Physicochemical Properties

Molecular Formula	C26H28CLFN8O4
Molecular Weight	571.00
CAS #	2701561-91-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of Novel Pyrido2,3-bPyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition. ChemMedChem. 2024 Dec 10:e202400629.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7513 mL	8.7566 mL	17.5131 mL
	5 mM	0.3503 mL	1.7513 mL	3.5026 mL
	10 mM	0.1751 mL	0.8757 mL	1.7513 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.