DMT-2'-OMe-D-Ribitol phosphoramidite (compound 9) is an abasic phosphoramidite monomer that can be used to introduce the abasic group Y34 into oligonucleotides.

Physicochemical Properties

Molecular Formula	C36H47N2O7P
Molecular Weight	650.74
CAS #	1470023-72-3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression. Nucleic Acids Res. 2013 Oct;41(18):8788-801.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5367 mL	7.6836 mL	15.3671 mL
	5 mM	0.3073 mL	1.5367 mL	3.0734 mL
	10 mM	0.1537 mL	0.7684 mL	1.5367 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.