Physicochemical Properties
| Molecular Formula | C3H7NO3 |
| Molecular Weight | 105.09258 |
| Exact Mass | 105.042 |
| CAS # | 302-84-1 |
| Related CAS # | DL-Serine-2,3,3-d3;70094-78-9 |
| PubChem CID | 617 |
| Appearance | White to off-white solid powder |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 394.8±32.0 °C at 760 mmHg |
| Melting Point | 240ºC (dec.) |
| Flash Point | 192.6±25.1 °C |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.519 |
| LogP | -1.58 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Heavy Atom Count | 7 |
| Complexity | 72.6 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | MTCFGRXMJLQNBG-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7) |
| Chemical Name | 2-amino-3-hydroxypropanoic acid |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro |
Tobacco leaves were treated with DL-Serine at a concentration of 0.01 M, followed by inoculation with Tobacco Mosaic Virus (TMV). The results showed that DL-Serine did not exhibit a significant inhibitory effect on the multiplication of TMV; instead, it slightly promoted the virus proliferation compared to the control group without DL-Serine treatment. [2] |
| ln Vivo |
In male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine, subcutaneous injection of DL-serine increased the number and size of tubular cell tumors [2]. Male Wistar rats were administered N-ethyl-N-hydroxyethylnitrosamine (EHEN) at a dose of 0.1% in drinking water for 2 weeks to induce renal tumorigenesis. Subsequently, the rats were given DL-Serine at a concentration of 1% in their diet for 24 weeks. The experiment revealed that DL-Serine significantly promoted the development of renal tumors induced by EHEN, with a higher incidence of renal tumors in the DL-Serine-treated group compared to the control group that received only EHEN. [1] |
| Cell Assay |
Tobacco plants were grown under controlled environmental conditions until they reached the 4-5 leaf stage. DL-Serine solution was prepared at a concentration of 0.01 M and applied to the surface of tobacco leaves by spraying until the leaves were uniformly wetted. After 24 hours of DL-Serine treatment, TMV suspension was inoculated onto the treated leaves by rubbing with carborundum. The inoculated plants were maintained under the same environmental conditions, and the degree of TMV multiplication was determined by measuring the virus titer in the leaves at specified time intervals using a bioassay method. [2] |
| Animal Protocol |
A total of 40 male Wistar rats (4 weeks old) were randomly divided into two groups: the experimental group and the control group, with 20 rats in each group. The control group received 0.1% EHEN in drinking water for 2 weeks, followed by a normal diet for 24 weeks. The experimental group was given 0.1% EHEN in drinking water for 2 weeks, and then a diet containing 1% DL-Serine for 24 weeks. Throughout the experiment, the rats had free access to food and water, and their general health status was monitored regularly. At the end of the 26-week experimental period, all rats were sacrificed, and their kidneys were dissected for pathological examination to assess the incidence and severity of renal tumors. [1] |
| References |
[1]. DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats. J Natl Cancer Inst. 1984 Jul;73(1):297-9. [2]. Effect of Alanine, Serine and Glutamic Acid on the Multiplication of Tobacco Mosaic Virus in Tobacco. Journal of Phytopathology. 1967, 58(1), 53-58. |
| Additional Infomation |
Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion. DL-Serine has been reported in Drosophila melanogaster, Populus tremula, and other organisms with data available. See also: Serine (annotation moved to). DL-Serine is an amino acid that can be metabolized in organisms. In the context of chemical-induced tumorigenesis, it may affect the process of renal tumor formation by regulating metabolic pathways or interacting with carcinogens. [1] DL-Serine is one of the common amino acids present in plants and organisms. This study explored its effect on plant virus multiplication to understand the interaction between amino acids and plant pathogens. [2] |
Solubility Data
| Solubility (In Vitro) |
H2O : ~33.33 mg/mL (~317.16 mM) DMSO :< 1 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (237.89 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.5157 mL | 47.5783 mL | 95.1565 mL | |
| 5 mM | 1.9031 mL | 9.5157 mL | 19.0313 mL | |
| 10 mM | 0.9516 mL | 4.7578 mL | 9.5157 mL |