D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature that has prebiotic properties. D-Tagatose is a substitute for sucrose and a low-calorie sweetener in foods such as chewing gum, juices and beverages. D-Tagatose is also a potential anti-diabetic active molecule studied in type II diabetes. It is also a prebiotic that helps increase beneficial bacteria in the colon, prevent colon cancer and lower cholesterol.

Physicochemical Properties

Molecular Formula	C6H12O6
Molecular Weight	180.16
Exact Mass	180.063
CAS #	87-81-0
Related CAS #	D-Tagatose-13C;478506-42-2;D-Tagatose-13C-1;478506-44-4
PubChem CID	2724552
Appearance	White to off-white solid powder
Density	1.6±0.1 g/cm3
Boiling Point	551.7±50.0 °C at 760 mmHg
Melting Point	130-136ºC
Flash Point	301.5±26.6 °C
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.574
LogP	-1.63
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Heavy Atom Count	12
Complexity	162
Defined Atom Stereocenter Count	4
SMILES	C1[C@H]([C@@H]([C@@H]([C@@](O1)(CO)O)O)O)O
InChi Key	LKDRXBCSQODPBY-VANKVMQKSA-N
InChi Code	InChI=1S/C6H12O6/c7-2-6(11)5(10)4(9)3(8)1-12-6/h3-5,7-11H,1-2H2/t3-,4+,5+,6+/m1/s1
Chemical Name	(2S,3S,4S,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Human Endogenous Metabolite
References	[1]. Trienzymatic Complex System for Isomerization of Agar-Derived d-Galactose into d-Tagatose as a Low-Calorie Sweetener. J Agric Food Chem. 2020;68(10):3195-3202.
Additional Infomation	Alpha-D-tagatopyranose is a D-tagatopyranose with an alpha-configuration at the anomeric center.

Solubility Data

Solubility (In Vitro)

DMSO :~100 mg/mL (~555.06 mM )

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (11.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (11.55 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (11.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.5506 mL	27.7531 mL	55.5062 mL
	5 mM	1.1101 mL	5.5506 mL	11.1012 mL
	10 mM	0.5551 mL	2.7753 mL	5.5506 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.