D-Arginine (HD-Arg-OH) is the D-isomer of Arginine. Arginine is an alpha-amino acid (AA) used in protein synthesis. D-Arginine is the inactive form of L-Arginine.

Physicochemical Properties

Molecular Formula	C6H14N4O2
Molecular Weight	174.20
Exact Mass	174.111
CAS #	157-06-2
Related CAS #	61155-84-8
PubChem CID	71070
Appearance	White to yellow solid powder
Density	1.5±0.1 g/cm3
Boiling Point	367.6±52.0 °C at 760 mmHg
Melting Point	221-224ºC
Flash Point	176.1±30.7 °C
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.601
LogP	-1.79
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Heavy Atom Count	12
Complexity	176
Defined Atom Stereocenter Count	1
SMILES	C(C[C@H](C(=O)O)N)CN=C(N)N
InChi Key	ODKSFYDXXFIFQN-SCSAIBSYSA-N
InChi Code	InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1
Chemical Name	(2R)-2-amino-5-(diaminomethylideneamino)pentanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Human Endogenous Metabolite
References	[1]. Toxicological and Pharmacological Effects of D-arginine. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):149-54.
Additional Infomation	D-arginine is a D-alpha-amino acid that is the D-isomer of arginine. It has a role as an EC 4.1.1.19 (arginine decarboxylase) inhibitor and a mouse metabolite. It is a D-alpha-amino acid and an arginine. It is a conjugate base of a D-argininium(1+). It is a conjugate acid of a D-argininate. It is an enantiomer of a L-arginine. A D-α-amino acid that is the D-isomer of arginine (only the L-form is physiologically active). D-Arginine has been reported in Homo sapiens with data available.

Solubility Data

Solubility (In Vitro)	H2O: 25 mg/mL (143.51 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (574.05 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.7405 mL	28.7026 mL	57.4053 mL
	5 mM	1.1481 mL	5.7405 mL	11.4811 mL
	10 mM	0.5741 mL	2.8703 mL	5.7405 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.