PeptideDB

Cyclorasin 9A5 TFA

Cyclorasin 9A5 TFA

CAS No.:

Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that inhibits Ras-Raf protein interaction with IC50 of
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Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that inhibits Ras-Raf protein interaction with IC50 of 120 nM.

Physicochemical Properties


Molecular Formula C75H108FN25O13.XC2HF3O2
Molecular Weight 1586.82 (free base)
Related CAS # Cyclorasin 9A5;1782098-79-6
Appearance White to off-white solid powder
Storage

Powder-20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity


Targets IC50: 120 nM (Ras-Raf protein interaction)[1].
References

[1]. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60(12):6567-6572.


Solubility Data


Solubility (In Vitro) H2O : ≥ 100 mg/mL