Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that improves PAF-induced enhanced SS erythrocyte adhesion, post-capillary occlusion, and hemodynamics and has cytotoxicity.

Physicochemical Properties

Molecular Formula	C28H40N8O7
Molecular Weight	600.67
CAS #	197172-76-2
SMILES	O=C1C2(CCCCC2)NC([C@@H](CC2C=CC=CC=2)NC([C@H](CC(=O)O)NC(CNC([C@H](CCC/N=C(\N)/N)N1)=O)=O)=O)=O
Synonyms	EMD 270179
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	aVβ3
References	[1]. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26(3):283-9. [2]. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1038-45.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6648 mL	8.3240 mL	16.6481 mL
	5 mM	0.3330 mL	1.6648 mL	3.3296 mL
	10 mM	0.1665 mL	0.8324 mL	1.6648 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.