Cyclo(RADfK) is a selective α(v)β(3) integrin ligand and is extensively utilized in the research related to neovascularization.

Physicochemical Properties

Molecular Formula	C28H43N9O7
Molecular Weight	617.697125673294
Exact Mass	617.329
CAS #	756500-23-9
PubChem CID	45107783
Appearance	White to off-white solid powder
Density	1.5±0.1 g/cm3
Index of Refraction	1.659
LogP	-2.75
Hydrogen Bond Donor Count	9
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	12
Heavy Atom Count	44
Complexity	1040
Defined Atom Stereocenter Count	5
SMILES	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O
InChi Key	SMFHXHGBDFBWOX-BWUHRYBWSA-N
InChi Code	InChI=1S/C28H43N9O7/c1-16-23(40)36-21(15-22(38)39)27(44)37-20(14-17-8-3-2-4-9-17)26(43)35-18(10-5-6-12-29)25(42)34-19(24(41)33-16)11-7-13-32-28(30)31/h2-4,8-9,16,18-21H,5-7,10-15,29H2,1H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)(H,37,44)(H,38,39)(H4,30,31,32)/t16-,18-,19-,20+,21-/m0/s1
Chemical Name	2-[(2S,5R,8S,11S,14S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-14-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Cyclo(RADfK) is a negative control for cyclo(-RGDfK-) (RGD peptide). RGD peptides are modulators of cell adhesion and are recognized by various members of the integrin family [1].
References	[1]. Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics withenhanced tumor-imaging and photosensitizing (PDT) efficacy. Mol Pharm. 2011 Aug 1;8(4):1186-1197.

Solubility Data

Solubility (In Vitro)	H2O : ~100 mg/mL (~161.89 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (161.89 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6189 mL	8.0945 mL	16.1891 mL
	5 mM	0.3238 mL	1.6189 mL	3.2378 mL
	10 mM	0.1619 mL	0.8095 mL	1.6189 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.