Cyclic(YCDGFYACYMDV) is a HER2 signaling inhibitor with anticancer activity. Cyclic(YCDGFYACYMDV) self-assembles into nanoparticles in aqueous solution and transforms into nanofibrils by targeting HER2 on cancer cells, disrupting HER2 dimerization and subsequent downstream signaling events, leading to cancer cell apoptosis. This inhibitory effect on HER2 breast cancer has been shown to be effective in a mouse xenograft model.

Physicochemical Properties

Molecular Formula	C65H82N12O20S3
Molecular Weight	1447.61
CAS #	535959-77-4
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HER2
References	[1]. Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo. Nat Nanotechnol. 2020 Feb;15(2):145-153.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6908 mL	3.4540 mL	6.9079 mL
	5 mM	0.1382 mL	0.6908 mL	1.3816 mL
	10 mM	0.0691 mL	0.3454 mL	0.6908 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.