Cyclazosin hydrochloride is an α1B-adrenoceptor antagonist. Cyclazosin hydrochloride is highly specific for α-adrenoceptors, with pKi values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la)- and OflB (alb)-adrenoceptors, respectively, but cannot distinguish between cloned alb and alo adrenoceptors (pKi values of 9.23 and 9.28, respectively).

Physicochemical Properties

Molecular Formula	C23H28CLN5O4
Molecular Weight	473.95
CAS #	146929-33-1
SMILES	Cl.COC1=C(OC)C=C2N=C(N3CCN(C(C4=CC=CO4)=O)[C@H]4CCCC[C@@H]34)N=C(N)C2=C1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist. Eur J Pharmacol. 1995 Dec 4;287(1):13-6.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1099 mL	10.5496 mL	21.0993 mL
	5 mM	0.4220 mL	2.1099 mL	4.2199 mL
	10 mM	0.2110 mL	1.0550 mL	2.1099 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.