Curdlan is a polysaccharide generated by bacteria and is a glucose homopolymer with β-1,3-glycosidic linkages.

Physicochemical Properties

Molecular Formula	(C6H10O5)N
Molecular Weight	504.43708
Exact Mass	504.169
CAS #	54724-00-4
Related CAS #	26874-89-5;133947-06-5
PubChem CID	64689
Appearance	White to yellow solid powder
Density	1.8±0.1 g/cm3
Boiling Point	902.8±65.0 °C at 760 mmHg
Flash Point	499.8±34.3 °C
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.673
LogP	-6.08
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Heavy Atom Count	12
Complexity	151
Defined Atom Stereocenter Count	5
SMILES	C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
InChi Key	WQZGKKKJIJFFOK-VFUOTHLCSA-N
InChi Code	InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
Chemical Name	(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Food Applications of Curdlan. Food Hydrocolloids pp 119-124.

Additional Infomation

Beta-D-glucose is d-Glucopyranose with beta configuration at the anomeric centre. It has a role as an epitope and a mouse metabolite. It is an enantiomer of a beta-L-glucose. A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Glucose oxidase has been investigated for the treatment of Upper Respiratory Tract Infections. b-D-Glucose is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol has been reported in Humulus lupulus, Maclura pomifera, and other organisms with data available. Beta-D-Glucopyranose is the beta isoform of D-glucopyranose, a synthetic simple monosaccharide as an energy source. D-glucopyranose is oxidized in various tissues either under aerobic or anaerobic conditions through glycolysis, and the oxidation reaction produces carbon dioxide, water and ATP. Zymosan is an insoluble beta-1,3-glucan polysaccharide derived from, and structural component of, yeast cell walls, with potential immunostimulating activity. Upon administration, zymosan targets, binds to and activates certain Toll-like receptors, primarily TLR type 2 (TLR-2), on leukocytes and dectin-1 on macrophages. Activation of TLR2 and dectin-1 stimulates the release of pro-inflammatory mediators, and enhances innate immune responses. Beta-D-Glucose is a metabolite found in or produced by Saccharomyces cerevisiae. See also: Zymosans (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 10 mg/mL 0.1 M NaOH: 1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9824 mL	9.9120 mL	19.8240 mL
	5 mM	0.3965 mL	1.9824 mL	3.9648 mL
	10 mM	0.1982 mL	0.9912 mL	1.9824 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.