Corypalmine is an alkaloid from Stephania cepharantha. Corypalmine is an antifungal drug.

Physicochemical Properties

Molecular Formula	C20H23NO4
Molecular Weight	341.4009
Exact Mass	341.163
CAS #	27313-86-6
Related CAS #	(-)-Corypalmine;6018-40-2
PubChem CID	185605
Appearance	White to off-white solid powder
Density	1.29g/cm3
Boiling Point	501.2ºC at 760mmHg
Flash Point	256.9ºC
LogP	3.011
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	25
Complexity	461
Defined Atom Stereocenter Count	0
InChi Key	BMCZTYDZHNTKPR-UHFFFAOYSA-N
InChi Code	InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3
Chemical Name	2,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-3-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Effect of Ent-norsecurinine, an Alkaloid, on Spore Germination of Some Fun. Mycobiology 30(4): 225-227 (2002).
Additional Infomation	(+/-)-Corypalmine has been reported in Corydalis ternata, Corydalis yanhusuo, and other organisms with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~33.33 mg/mL (~97.63 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.32 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.32 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9291 mL	14.6456 mL	29.2912 mL
	5 mM	0.5858 mL	2.9291 mL	5.8582 mL
	10 mM	0.2929 mL	1.4646 mL	2.9291 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.