Conteltinib tetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. Conteltinib tetrahydrochloride is an inhibitor of FAK (IC50=1.6 nM), ALK and Pyk2. Conteltinib tetrahydrochloride has synergistic anti-tumor effects when used in combination with Cabozantinib.

Physicochemical Properties

Molecular Formula	C32H49CL4N9O3S
Molecular Weight	781.67
Related CAS #	Conteltinib;1384860-29-0
Appearance	Solid powder
Synonyms	CT-707 tetrahydrochloride
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. CT-707, a Novel FAK Inhibitor, Synergizes with XL184 to Suppress Hepatocellular Carcinoma by Blocking XL184-Induced FAK Activation. Mol Cancer Ther. 2016 Dec;15(12):2916-2925.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~127.93 mM; with ultrasonication (<60°C))

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.2793 mL	6.3966 mL	12.7931 mL
	5 mM	0.2559 mL	1.2793 mL	2.5586 mL
	10 mM	0.1279 mL	0.6397 mL	1.2793 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.