Clobetasone Butyrate (SN203; Emovate; SN-203; Eumovate; Cloptison; Molivate), the 17-O-butyl ester of Clobetasone, is a corticosteroid that has been used in dermatology for the treatment of skin inflammation such as eczema, psoriasis.
Physicochemical Properties
| Molecular Formula | C26H32CLFO5 |
| Molecular Weight | 478.9854 |
| Exact Mass | 478.192 |
| CAS # | 25122-57-0 |
| Related CAS # | 54063-32-0;25122-57-0 (butyrate); |
| PubChem CID | 71386 |
| Appearance | White to off-white solid powder |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 573.3±50.0 °C at 760 mmHg |
| Melting Point | 179 °C |
| Flash Point | 181.1±19.3 °C |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.551 |
| LogP | 4.82 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 6 |
| Heavy Atom Count | 33 |
| Complexity | 987 |
| Defined Atom Stereocenter Count | 7 |
| SMILES | CCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(CC(=O)[C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)C)C)C(=O)CCl |
| InChi Key | FBRAWBYQGRLCEK-AVVSTMBFSA-N |
| InChi Code | InChI=1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1 |
| Chemical Name | [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate |
| Synonyms | SN203 Clobetasone 17-butyrate Clobetasone ButyrateSN203 EmovateSN-203GR 2/1214SN 203EumovateCloptisonMolivate |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vivo | The application of clobetazone butyrate (0.05%; 7 weeks) topically may result in thinned epidermis. For a period of seven weeks, clobetazone butyrate had a significantly less effect on epidermal thinning in pigs than flunandrolone (0.05%). or 0.025 percent fluocinolone acetonide, both of which thin the skin of pigs. extreme atrophy [1]. |
| Animal Protocol |
Animal/Disease Models: Large white domestic pig [1] Doses: 0.5% Skin application administration time: 7 weeks Experimental Results: Caused moderate to mild atrophy. |
| References |
[1]. Clobetasone butyrate, a new topical corticosteroid: clinical activity and effects on pituitary-adrenal axis function and model of epidermal atrophy. [2]. Clobetasone butyrate for inflammatory skin conditions. |
| Additional Infomation | Clobetasone butyrate is an organic molecular entity. |
Solubility Data
| Solubility (In Vitro) | DMSO : ≥ 250 mg/mL (~521.94 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (13.05 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0877 mL | 10.4386 mL | 20.8773 mL | |
| 5 mM | 0.4175 mL | 2.0877 mL | 4.1755 mL | |
| 10 mM | 0.2088 mL | 1.0439 mL | 2.0877 mL |