Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. The proagent of Clindamycin (HY-B1455), clindamycin phosphate, has no antimicrobial activity in vitro but can be quickly hydrolyzed by phosphatase ester in vivo to become the active parent agent, Clindamycin. One can use clindamycin phosphate to study bacterial vaginosis and acne.

Physicochemical Properties

Molecular Formula	C18H34CLN2O8PS
Molecular Weight	504.95
Exact Mass	504.146
Elemental Analysis	C, 42.81; H, 6.79; Cl, 7.02; N, 5.55; O, 25.35; P, 6.13; S, 6.35
CAS #	24729-96-2
Related CAS #	Clindamycin hydrochloride;21462-39-5;Clindamycin palmitate hydrochloride;25507-04-4;Clindamycin;18323-44-9;Clindamycin phosphate hydrochloride;64023-51-4
PubChem CID	443385
Appearance	White to off-white solid powder.
Density	1.4±0.1 g/cm3
Boiling Point	159°C
Melting Point	114ºC
Index of Refraction	1.577
LogP	0.93
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Heavy Atom Count	31
Complexity	658
Defined Atom Stereocenter Count	9
SMILES	Cl[C@@]([H])(C([H])([H])[H])[C@]([H])([C@]1([H])[C@@]([H])([C@@]([H])([C@]([H])([C@]([H])(O1)SC([H])([H])[H])OP(=O)(O[H])O[H])O[H])O[H])N([H])C([C@]1([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])[H])=O
InChi Key	UFUVLHLTWXBHGZ-MGZQPHGTSA-N
InChi Code	InChI=1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12+,13+,14-,15+,16+,18+/m0/s1
Chemical Name	(2R,3R,4S,5R,6R)-6-((1S,2S)-2-chloro-1-((2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2H-pyran-3-yl dihydrogen phosphate
Synonyms	Cleocin T; Clinda-Derm; Clindagel; Evoclin; U 28508; U-28508; U28508
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Antibiotic, Bacterial
References	[1]. Eur J Clin Pharmacol. 2017 Feb;73(2):251-253. [2]. J Dermatol. 2018 Aug;45(8):951-962. [3]. Gynecol. 2020, 47(4), 516–518. [4]. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38.
Additional Infomation	Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate is used in topical preparations. See also: Clindamycin (has active moiety); Benzoyl Peroxide; Clindamycin Phosphate (component of); Clindamycin phosphate; tretinoin (component of) ... View More ...

Solubility Data

Solubility (In Vitro)	H2O : 100 mg/mL (198.04 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 50 mg/mL (99.02 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9804 mL	9.9020 mL	19.8039 mL
	5 mM	0.3961 mL	1.9804 mL	3.9608 mL
	10 mM	0.1980 mL	0.9902 mL	1.9804 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.