Cidofovir diphosphate tri(triethylamine), an active intracellular metabolite of Cidofovir, is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively. Cidofovir (CDV) is a broad-spectrum antiviral agent that has been approved for clinical use in the treatment of cytomegalovirus retinitis. It has also been used off label to treat a variety of other viral infections, including those caused by orf and molluscum contagiosum poxviruses. Because it is a dCMP analog, CDV is thought to act by inhibiting viral DNA polymerases.

Physicochemical Properties

Molecular Formula	C26H61N6O12P3
Molecular Weight	742.72
Related CAS #	Cidofovir diphosphate;142276-31-1
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	HCMV, HSV-1, HSV-2, human α, human β, and human γ DNA polymerase are all inhibited by cidofovir diphosphate tritriethylamine (0-1000 μM), with corresponding Ki values of 6.6, 0.86, 1.4, 51, 520, and 300 μM[1]. The vaccinia virus DNA polymerase has a Km value of 23 μM and is inhibited by cidofovir diphosphate tritriethylamine (0.3-30 μM)[2].
References	[1]. Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity. 1996. [2]. Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob Agents Chemother. 2005 Aug;49(8):3153-62.

Solubility Data

Solubility (In Vitro)	May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
Solubility (In Vivo)	Solubility in Formulation 1: 12.5 mg/mL (16.83 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3464 mL	6.7320 mL	13.4640 mL
	5 mM	0.2693 mL	1.3464 mL	2.6928 mL
	10 mM	0.1346 mL	0.6732 mL	1.3464 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.