Chromafenozide (ANS118) is a lepidopteran insecticide that can effectively control a variety of lepidopteran pests.

Physicochemical Properties

Molecular Formula	C24H30N2O3
Molecular Weight	394.51
Exact Mass	394.226
CAS #	143807-66-3
PubChem CID	10157484
Appearance	White to off-white solid powder
Density	1.129g/cm3
Melting Point	186.4°
Index of Refraction	1.574
LogP	4.913
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	29
Complexity	589
Defined Atom Stereocenter Count	0
SMILES	O=C(C1=CC=C2C(CCCO2)=C1C)NN(C(C3=CC(C)=CC(C)=C3)=O)C(C)(C)C
InChi Key	HPNSNYBUADCFDR-UHFFFAOYSA-N
InChi Code	InChI=1S/C24H30N2O3/c1-15-12-16(2)14-18(13-15)23(28)26(24(4,5)6)25-22(27)20-9-10-21-19(17(20)3)8-7-11-29-21/h9-10,12-14H,7-8,11H2,1-6H3,(H,25,27)
Chemical Name	N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-5-methyl-3,4-dihydro-2H-chromene-6-carbohydrazide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Chromafenozide is a bisacylhydrazine insecticide. It is functionally related to a benzohydrazide.

Solubility Data

Solubility (In Vitro)

DMSO: 250 mg/mL (633.70 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (5.27 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.27 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5348 mL	12.6739 mL	25.3479 mL
	5 mM	0.5070 mL	2.5348 mL	5.0696 mL
	10 mM	0.2535 mL	1.2674 mL	2.5348 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.