Chloramphenicol palmitate is an orally bioactive broad spectrum (a wide range) antibiotic with broad activity against Gram-positive (Gram+) and Gram-negative (Gram-) bacteria. Chloramphenicol palmitate inhibits bacterial protein synthesis by blocking the synthesis of peptidyl transferases. Chloramphenicol palmitate can be used as a bacterial selection agent for transformed cells containing chloramphenicol resistance genes.

Physicochemical Properties

Molecular Formula	C27H42CL2N2O6
Molecular Weight	561.54
Exact Mass	560.242
CAS #	530-43-8
Related CAS #	Chloramphenicol;56-75-7
PubChem CID	443382
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	691.6±55.0 °C at 760 mmHg
Melting Point	90ºC
Flash Point	372.1±31.5 °C
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.526
LogP	9.04
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	21
Heavy Atom Count	37
Complexity	639
Defined Atom Stereocenter Count	2
SMILES	CCCCCCCCCCCCCCCC(OC[C@H]([C@@H](C1=CC=C([N+]([O-])=O)C=C1)O)NC(C(Cl)Cl)=O)=O
InChi Key	PXKHGMGELZGJQE-ILBGXUMGSA-N
InChi Code	InChI=1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
Chemical Name	[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Chloramphenicol palmitate is a hexadecanoate ester. It is functionally related to a chloramphenicol. See also: Chloramphenicol (has active moiety).

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~178.08 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (4.45 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7808 mL	8.9041 mL	17.8082 mL
	5 mM	0.3562 mL	1.7808 mL	3.5616 mL
	10 mM	0.1781 mL	0.8904 mL	1.7808 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.