Chitinase-IN-1 is an insecticide that can inhibit the activities of chitosanase and acetylhexosaminidase. The inhibition percentages of 50 uM and 20 uM concentrations for polysaccharase and acetylhexosaminidase are 75% and 75% respectively. 67%.

Physicochemical Properties

Molecular Formula	C18H16N4O2S
Molecular Weight	352.41
Exact Mass	352.099
CAS #	1579991-61-9
PubChem CID	86223063
Appearance	Typically exists as solid at room temperature
Density	1.4±0.1 g/cm3
Boiling Point	589.5±35.0 °C at 760 mmHg
Flash Point	310.3±25.9 °C
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.694
LogP	1.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	25
Complexity	501
Defined Atom Stereocenter Count	0
SMILES	S1C(C([H])([H])[H])=NN=C1C([H])([H])N([H])C([H])([H])C([H])([H])N1C(C2=C([H])C([H])=C([H])C3C([H])=C([H])C([H])=C(C1=O)C2=3)=O
InChi Key	YHPDOCZSFWEMOD-UHFFFAOYSA-N
InChi Code	InChI=1S/C18H16N4O2S/c1-11-20-21-15(25-11)10-19-8-9-22-17(23)13-6-2-4-12-5-3-7-14(16(12)13)18(22)24/h2-7,19H,8-10H2,1H3
Chemical Name	2-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)methylamino]ethyl]benzo[de]isoquinoline-1,3-dione
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. thalimide derivative and application thereof as enzyme inhibitor and pesticide . Patent CN 103641825 A

Solubility Data

Solubility (In Vitro)

DMSO: 50 mg/mL (141.88 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.75 mg/mL (7.80 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.75 mg/mL (7.80 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8376 mL	14.1880 mL	28.3760 mL
	5 mM	0.5675 mL	2.8376 mL	5.6752 mL
	10 mM	0.2838 mL	1.4188 mL	2.8376 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.