Carsalam (Carbonylsalicylamide) is a non-steroidal anti~inflammatory agent.

Physicochemical Properties

Molecular Formula	C8H5NO3
Molecular Weight	163.1302
Exact Mass	163.026
CAS #	2037-95-8
PubChem CID	16258
Appearance	Typically exists as solid at room temperature
Density	1.4±0.1 g/cm3
Melting Point	228-232ºC(lit.)
Index of Refraction	1.586
LogP	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Heavy Atom Count	12
Complexity	226
Defined Atom Stereocenter Count	0
SMILES	O1C(N([H])C(C2=C([H])C([H])=C([H])C([H])=C12)=O)=O
InChi Key	OAYRYNVEFFWSHK-UHFFFAOYSA-N
InChi Code	InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11)
Chemical Name	1,3-benzoxazine-2,4-dione
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Carsalam is a benzoxazine.

Solubility Data

Solubility (In Vitro)

DMSO : ~120 mg/mL (~735.61 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 3 mg/mL (18.39 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 3 mg/mL (18.39 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.1301 mL	30.6504 mL	61.3008 mL
	5 mM	1.2260 mL	6.1301 mL	12.2602 mL
	10 mM	0.6130 mL	3.0650 mL	6.1301 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.