Capeserod (SL65.0155 free base) is a serotonin receptor (5-HT receptor) agonist with a Ki of 0.6 nM for 5-HT4 receptor. Capeserod enhances the expression of phosphorylated cAMP response element binding protein (p-CREB), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and B-cell lymphoma-2 protein (Bcl-2) in the hippocampus and exhibits antidepressant activity in the Wistar rat model.

Physicochemical Properties

Molecular Formula	C23H25CLN4O4
Molecular Weight	456.92
CAS #	769901-96-4
Appearance	White to off-white solid powder
SMILES	O=C1OC(C2=C3C(OCCO3)=C(N)C(Cl)=C2)=NN1C4CCN(CCC5=CC=CC=C5)CC4
Synonyms	SL65.0155 free base
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	5-HT4 Receptor 0.6 nM (Ki)
References	[1]. Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1205-10.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~218.86 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (10.94 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1886 mL	10.9428 mL	21.8857 mL
	5 mM	0.4377 mL	2.1886 mL	4.3771 mL
	10 mM	0.2189 mL	1.0943 mL	2.1886 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.