Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate targeting HER2, which is connected to a payload consisting of a linker (XMT-1519 conjugate-1) and a STING agonist (STING agonist-20), and has potential immune activation and anti-tumor activity.

Physicochemical Properties

CAS #	2847102-44-5
Synonyms	XMT-2056
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HER2
References	[1]. XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumabJ. Cancer Res, 2022, 82(12_Supplement): 3503-3503.

Solubility Data