CYP11A1-IN-1 (compound 30) is an inhibitor (blocker/antagonist) of CYP11A1 with IC50 of 201-2000 nM. CYP11A1-IN-1 may be utilized in the research of steroid receptors, particularly androgen receptor-dependent diseases and conditions, such as prostate cancer.

Physicochemical Properties

Molecular Formula	C27H34N2O5
Molecular Weight	466.57
CAS #	2744168-51-0
Appearance	White to light yellow solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CYP11A1[1]
References	[1]. Preparation of substituted pyran-4-ones and 2-((cyclo)alkylsulfonyl)phenols as CYP11A1 inhibitors. World Intellectual Property Organization, WO2021229152 A1. 2021-11-18.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (214.33 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (5.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1433 mL	10.7165 mL	21.4330 mL
	5 mM	0.4287 mL	2.1433 mL	4.2866 mL
	10 mM	0.2143 mL	1.0717 mL	2.1433 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.