CSLP37 is a selective RIPK2 inhibitor with IC50 of 16.3 nM. CSLP37 has no inhibitory activity against RIPK1 and RIPK3. CSLP37 shows potent inhibition of cellular NOD1 and NOD2 responses.

Physicochemical Properties

Molecular Formula	C25H30FN5O3S
Molecular Weight	499.60
CAS #	2244984-64-1
SMILES	S(CCC)(NC1C(=C(C=C(C=1)C1=C(N)N=CC(=C1)C1C=CC(=CC=1)N1CCNCC1)F)OC)(=O)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	RIPK2 16.3 nM (IC50)
References	[1]. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37(17):e99372.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0016 mL	10.0080 mL	20.0160 mL
	5 mM	0.4003 mL	2.0016 mL	4.0032 mL
	10 mM	0.2002 mL	1.0008 mL	2.0016 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.