CQ-16 is an orally active small molecule drug conjugate (SMDC) targeting prostate-specific membrane antigen (PSMA). CQ-16 exhibits highly selective antiproliferative activity between PSMA-positive and PSMA-negative prostate cells. In addition, CQ-16 also has PARP inhibitory activity (IC50=1 nM). (Pink: PSMA Ligand; Black: Linker; Blue: PARP Inhibitor)

Physicochemical Properties

Molecular Formula	C40H47FN8O12
Molecular Weight	850.85
CAS #	3024354-59-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A Prostate-Specific Membrane Antigen-Targeting Small Molecule–Drug Conjugate Strategy to Overcome the Hematological Toxicity of OlaparibJ. Journal of Medicinal Chemistry, 2024.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1753 mL	5.8765 mL	11.7530 mL
	5 mM	0.2351 mL	1.1753 mL	2.3506 mL
	10 mM	0.1175 mL	0.5876 mL	1.1753 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.