CPN-219, a new generation hexapeptide NMUR2 agonist, achieved dose-dependent and selective activation of NMUR2 with an EC50 value of 2.2 nM.

Physicochemical Properties

Molecular Formula	C40H72N12O8
Molecular Weight	849.08
CAS #	2240202-02-0
Appearance	White to off-white solid powder
SMILES	C(N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)N)CC(=O)N)(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CCC1CCCCC1
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Animal Protocol	Animal/Disease Models:ddY mice[1]. Doses: 250, 100, 25 µg/mouse. Route of Administration: Applied to the nasal cavity. Experimental Results: Suppressed body weight gain of mice in a dose-dependent manner.
References	[1]. A chemically stable peptide agonist to neuromedin U receptor type 2. Bioorg Med Chem. 2020 May 15;28(10):115454.

Solubility Data

Solubility (In Vitro)	May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
Solubility (In Vivo)	CPN-219 was dissolved in saline[1]. (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1777 mL	5.8887 mL	11.7775 mL
	5 mM	0.2355 mL	1.1777 mL	2.3555 mL
	10 mM	0.1178 mL	0.5889 mL	1.1777 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.