CKD-519 is a potent and specific inhibitor of cholesteryl ester transfer protein (CETP). CKD-519 inhibits CETP-mediated cholesteryl ester transfer in human serum with IC50 of 2.3 nM.

Physicochemical Properties

Molecular Formula	C31H34F7NO3
Molecular Weight	601.595393657684
Exact Mass	601.242
CAS #	1402796-27-3
PubChem CID	70674853
Appearance	White to off-white solid powder
LogP	8.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Heavy Atom Count	42
Complexity	986
Defined Atom Stereocenter Count	2
SMILES	FC1C=C(C(=CC=1C(C)C)C1CCC(C)(C)CC=1CN1C(=O)O[C@H](C2C=C(C(F)(F)F)C=C(C(F)(F)F)C=2)[C@@H]1C)OC
InChi Key	GBHPDJQHZADVAA-SOKVYYICSA-N
InChi Code	InChI=1S/C31H34F7NO3/c1-16(2)23-12-24(26(41-6)13-25(23)32)22-7-8-29(4,5)14-19(22)15-39-17(3)27(42-28(39)40)18-9-20(30(33,34)35)11-21(10-18)31(36,37)38/h9-13,16-17,27H,7-8,14-15H2,1-6H3/t17-,27-/m0/s1
Chemical Name	(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)-5,5-dimethylcyclohexen-1-yl]methyl]-4-methyl-1,3-oxazolidin-2-one
Synonyms	CKD519; CKD 519; CKD-519
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects. Drug Des Devel Ther. 2016 Nov 15;10:3763-3770.
Additional Infomation	Rocacetrapib is under investigation in clinical trial NCT02156544 (Study to Investigate the Safety/Tolerability and Pharmacokinetics/Pharmacodynamics of CKD-519).

Solubility Data

Solubility (In Vitro)

DMSO : ~66.67 mg/mL (~110.82 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6622 mL	8.3112 mL	16.6223 mL
	5 mM	0.3324 mL	1.6622 mL	3.3245 mL
	10 mM	0.1662 mL	0.8311 mL	1.6622 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.