CHDI-00484077 (Compound 12) is a CNS-penetrant class IIa HDAC inhibitor with IC50s of 0.01 μM (HDAC4), 0.02 μM (HDAC5), 0.02 μM (HDAC7), 0.03 μM (HDAC9). CHDI-00484077 can be used in the study of Huntington's disease.

Physicochemical Properties

Molecular Formula	C18H21F3N4O2
Molecular Weight	382.38
CAS #	3025894-92-9
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HDAC4 0.01 μM (IC50); HDAC5 0.02 μM (IC50); HDAC7 0.02 μM (IC50); HDAC9 0.03 μM (IC50); HDAC1 17 μM (IC50); HDAC2 27 μM (IC50); HDAC3 10 μM (IC50); HDAC8 2.0 μM (IC50); HDAC6 22 μM (IC50)
References	[1]. Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. ACS Med Chem Lett. 2021 Feb 11;12(3):380-388.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6152 mL	13.0760 mL	26.1520 mL
	5 mM	0.5230 mL	2.6152 mL	5.2304 mL
	10 mM	0.2615 mL	1.3076 mL	2.6152 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.