CG-3-246 is a dual inhibitor of FLT3/BCL-2 with Kd of 63 and 4.25 nM, respectively. CG-3-246 plays an important role in the research of acute myeloid leukemia.

Physicochemical Properties

Molecular Formula	C64H73CLN14O10S
Molecular Weight	1265.87
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN–GIL hybrid single-molecule inhibitors. Eur J Med Chem. 2024 Dec 22:285:117190.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.7900 mL	3.9499 mL	7.8997 mL
	5 mM	0.1580 mL	0.7900 mL	1.5799 mL
	10 mM	0.0790 mL	0.3950 mL	0.7900 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.