CDK8-IN-17 (Compound WS-2) is a CDK8 inhibitor with IC50 of 9 nM, which can be used in cancer research.

Physicochemical Properties

Molecular Formula	C21H20N4OS
Molecular Weight	376.47
CAS #	451458-32-5
SMILES	C1(SCC2=CC=CC=C2C)N(C2=CC=C(CC)C=C2)C(=O)C2C=NNC=2N=1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CDK8 9 nM (IC50)
References	[1]. Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screeningJ. European journal of medicinal chemistry, 2017, 129: 275-286.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6563 mL	13.2813 mL	26.5625 mL
	5 mM	0.5313 mL	2.6563 mL	5.3125 mL
	10 mM	0.2656 mL	1.3281 mL	2.6563 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.