CDK4/6-IN-18 (Example 2BrIC) is a selective CDK4/6 inhibitor. CDK4/6-IN-18 inhibits ionizing radiation (IR)-induced cellular DNA damage

Physicochemical Properties

Molecular Formula	C20H10BRN3O2
Molecular Weight	404.22
CAS #	546102-60-7
SMILES	BrC=1C=CC2=C(C1)NC3=C4NC5=CC=CC=C5C4=C6C(=C23)C(NC6=O)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CDK4 CDK6
References	[1]. Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors. Patent. WO2010051127 A2.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4739 mL	12.3695 mL	24.7390 mL
	5 mM	0.4948 mL	2.4739 mL	4.9478 mL
	10 mM	0.2474 mL	1.2370 mL	2.4739 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.