CCT239065 is an orally available, potent inhibitor of mutant protein kinase V600EBRAF (RAF) with anti-tumor activity. CCT239065 inhibits V600EBRAF downstream signaling in cancer cells, blocks DNA synthesis, and inhibits proliferation.

Physicochemical Properties

Molecular Formula	C29H29N7O3S
Molecular Weight	555.65
CAS #	1163719-51-4
SMILES	S(C)C1C=C(C=CC=1NC(NC1=CC(C(C)(C)C)=NN1C1C=CC(C)=CC=1)=O)OC1C=CN=C2C=1N=CC(N2)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF. Cancer Res. 2010 Oct 15;70(20):8036-44. [2]. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget. 2012 Oct;3(10):1068-111.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7997 mL	8.9985 mL	17.9969 mL
	5 mM	0.3599 mL	1.7997 mL	3.5994 mL
	10 mM	0.1800 mL	0.8998 mL	1.7997 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.