CBX-12 is a PDC (peptide drug conjugate) that targets tumors in an antigen-independent manner and has anti-tumor activity. CBX-12 consists of a pH-sensitive peptide (pHLIP), an autoimmune linker, and Exatecan, a topoisomerase 1 (TOP1) inhibitor.

Physicochemical Properties

Molecular Formula	C169H240FN35O49S2
Molecular Weight	3629.05
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Topoisomerase I
References	[1]. CBX-12-101: A first-in-human study of CBX-12, an alphalex peptide drug conjugate (PDC) in patients (pts) with advanced or metastatic solid tumorsJ. 2023.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.2756 mL	1.3778 mL	2.7555 mL
	5 mM	0.0551 mL	0.2756 mL	0.5511 mL
	10 mM	0.0276 mL	0.1378 mL	0.2756 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.