CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 bromodomain family. CBP/p300-IN-8 inhibits CBP (IC50=0.01-0.1 µM) and BRD4 (IC50=1-1000 µM) activity.

Physicochemical Properties

Molecular Formula	C27H31N3O4
Molecular Weight	461.552747011185
Exact Mass	461.231
CAS #	2304416-91-7
PubChem CID	142545683
Appearance	White to off-white solid powder
LogP	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	34
Complexity	741
Defined Atom Stereocenter Count	3
SMILES	OC([C@H]1CCC[C@@H](C1)N1C(CC2C=CC=CC=2)=NC2=C3C(=CC=C12)N(C(=O)OC)[C@@H](C)CC3)=O
InChi Key	ABNLUJMIBRFYRV-IHPCNDPISA-N
InChi Code	InChI=1S/C27H31N3O4/c1-17-11-12-21-22(29(17)27(33)34-2)13-14-23-25(21)28-24(15-18-7-4-3-5-8-18)30(23)20-10-6-9-19(16-20)26(31)32/h3-5,7-8,13-14,17,19-20H,6,9-12,15-16H2,1-2H3,(H,31,32)/t17-,19-,20-/m0/s1
Chemical Name	(1S,3S)-3-[(7S)-2-benzyl-6-methoxycarbonyl-7-methyl-8,9-dihydro-7H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CBP 0.01-0.1 μM (IC50) BRD4 1-1000 μM (IC50)
References	[1]. Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors. WO2019055877A1.

Solubility Data

Solubility (In Vitro)

DMSO : 200 mg/mL (433.32 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (10.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1666 mL	10.8331 mL	21.6661 mL
	5 mM	0.4333 mL	2.1666 mL	4.3332 mL
	10 mM	0.2167 mL	1.0833 mL	2.1666 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.