CB2 receptor agonist 8 (Compound 17) is an agonist of cannabinoid receptor 2 (CB2 receptor). CB2 receptor agonist 8 exhibits cytotoxicity in U87, RPMI 8226, HL-60 and L929 cells with IC50 of 91.03, 16.29, 23.51 and 564.6 μM, respectively. CB2 receptor agonist 8 activates caspase 3/7, increases the expression of pro-apoptotic genes BAX, BAD, BIM and tumor suppressor gene p53, and induces apoptosis in U87. CB2 receptor agonist 8 inhibits the migration of U87 cells.

Physicochemical Properties

Molecular Formula	C23H26FN3O2
Molecular Weight	395.47
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CB2R
References	[1]. Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies. Bioorg Chem. 2024 Jul;148:107429.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5286 mL	12.6432 mL	25.2864 mL
	5 mM	0.5057 mL	2.5286 mL	5.0573 mL
	10 mM	0.2529 mL	1.2643 mL	2.5286 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.