CAY10406 is an inhibitor of caspase 3/7. CAY10406 inhibits the expression of the 28 kDa IL-1β fragment without significant cytotoxicity (10 μM).

Physicochemical Properties

Molecular Formula	C27H23F3N2O5S
Molecular Weight	544.54
CAS #	2108603-03-6
SMILES	N1(CC2=CC=CC=C2)C2=C(C=C(S(N3CCC[C@H]3COC3=CC=C(C(F)(F)F)C=C3)(=O)=O)C=C2)C(=O)C1=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Autoimmune inner ear disease patient-associated 28-kDa proinflammatory IL-1β fragment results from caspase-7-mediated cleavage in vitro. JCI Insight. 2020 Feb 13;5(3):e130845.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8364 mL	9.1821 mL	18.3641 mL
	5 mM	0.3673 mL	1.8364 mL	3.6728 mL
	10 mM	0.1836 mL	0.9182 mL	1.8364 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.